Plant, Animal & Microbe Genomes X Conference Plant, Animal & Microbe Genomes X ConferenceJanuary 12-16, 2002
Town & Country Convention Center
San Diego, CA
Workshop: Databases, Gene Systematics, and Nomenclature
The genome sequencing projects are providing a vast amount of sequence data that remains largely unexploited. Proteome analysis has become indispensable and complementary to genomic analysis. The European Bioinformatics Institute provides a suite of key resources for the analysis of completed proteomes. Sequences: The protein sequence databases SWISS-PROT, TrEMBL and TrEMBLnew cover all publicly known protein sequences grouped by their annotation status. All incoming data goes to TrEMBLnew, is cleaned from redundancy, automatically annotated and stored in TrEMBL, manually annotated, triple-checked and released as finished entry into SWISS-PROT. Families and domains: InterPro is a collaboration of SWISS-PROT + TrEMBL, PROSITE, PRINTS, Pfam, SMART and ProDom. As of October 2001, InterPro contains 7802 protein signatures linked to 3939 manually annotated entries. InterPro enabled us to provide a series of analysis pages for all the completely sequenced organisms at www.ebi.ac.uk/proteome/. Clusters: Based on pairwise sequence similarity, we launched a database of clusters of SWISS-PROT + TrEMBL proteins, abbreviated CluSTr. As of October 2001, it covers more than 40 completed proteomes. Proteome analysis pages: We set up a collection of web pages for each finished organism. They provide easy access to the complete set of protein sequences, statistics on primary, secondary and tertiary structure data, InterPro based family and domain information, a list of interesting clusters, functional classification based on the GeneOntology, and a tool to compare each organism to each other finished proteome. The proteome analysis pages are accessible at http://www.ebi.ac.uk/proteome/.