PAG-X  Plant, Animal & Microbe Genomes X Conference

January 12-16, 2002
Town & Country Convention Center
San Diego, CA


Workshop: Controlled Vocabulary/Ontology
            


THE USE OF THE GENE ONTOLOGY AND OTHER CONTROLLED VOCABULARIES IN THE MOUSE GENOME INFORMATICS DATABASES

Harold J. Drabkin1 , Joel E Richardson1 , Martin Ringwald1 , Jim A Kadin1 , Janan T Eppig1 , Judith A Blake1

1 The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA

The Mouse Genome Informatics (MGI) system makes extensive use of controlled vocabularies. Controlled vocabularies (CV) not only aid queries of the dataset, but also facilitate computational data curation and data mining, expedite hand curation, and support data integration. MGI contributes to the development and implementation of the Gene Ontology (GO) system. In MGI, the GO is used to describe a gene product in terms of the function it performs, the process that the function is part of, and the cellular compartment or complex in which it is found. Additional CVs used in MGI include an anatomical dictionary developed in collaboration with University of Edinburgh, Scotland and a structured vocabulary to describe phenotypic abnormalities in mouse.

The MGI resource is a public, comprehensive information system representing the genomics and genetics of the laboratory mouse. From genotype to phenotype, this resource integrates information about sequences, maps, mammalian homology, genes, expression analyses, alleles, strains and mutant phenotypes. The Mouse Genome Database (MGD) and the Gene Expression Database (GXD) are two components of this system.

MGD is supported by NHGRI grant HG-00330. GXD is supported by National Institute of Child Health and Human Development grant HD33745. The GO work at MGI is supported by NHGRI grant HG-02273


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