Plant, Animal & Microbe Genomes X Conference Plant, Animal & Microbe Genomes X ConferenceJanuary 12-16, 2002
Town & Country Convention Center
San Diego, CA
Workshop: Comparative Genomics
Comparative genomics is rapidly gaining importance. With the elucidation of the complete sequence of large numbers of genomes, a vast knowledge base is being created. Researchers need to access this information in efficient ways. We have created a genome comparison software, which allows the analysis of eu-and prokaryotic genomes. Information about protein families and synteny, as well as homology and orthology relationships between genomes is collected and stored in specialized databases. A selection of entire genomes (e.g. human, mouse, fly, worm, yeasts, plants, bacteria) are included in the system. In addition, the user can add any number of genomes or transcriptomes of choice. Advanced querying capabilities allow the retrieval of a wealth of information about individual genes, gene clusters or entire genomes. Results are graphically visualized with syntenic chromosomal regions aligned to one another. The user can quickly identify unique or ubiquitous regions in any genome of interest. As a result, this system has major applications in R&D, ranging from the discovery of genetic diseases or drug targets, to the development of anti-infectants and biotechnology, as well as the annotation of genomes from lifestock or agricultural important plants and pathogens. We will present results obtained from the analysis of genomes of higher eukaryotes as well as pathogenic micro-organisms.