PAG-X  Plant, Animal & Microbe Genomes X Conference

January 12-16, 2002
Town & Country Convention Center
San Diego, CA


Poster: Bioinformatics for Microbial Genomics
           Computer: Demo Only


INTEGRATED GENOME RESOURCES AT NCBI.

Tatiana A. Tatusova1

1 NCBI/NLM/NIH Bldg. 38A 8600 Rockville Pike, Bethesda, MD 20894

Genomes section of Entrez provides access to over 1,000 records that represent more than 900 different species including over 700 viruses, > 50 micorbial genomes, specially curated set of organelles and a number of viroids, and broad host range plasmids. The National Center for Biotechnology Information (NCBI) is providing useful access to these data through Entrez search and retrieval engine and visualize the sequence and map (genetic and physical) information at varying levels of detail. Primary resources include phylogenetically organized displays, precomputed relationships and direct access to analytical tools allowing evolutionary, structural and similarity-based perspectives of the data. A recently developed BLink (BLAST Link) resource displays the graphical output of pre-computed blastp results against the protein non-redundant (nr) database. BLink intgerates heterogenious NCBI resources offering a variety of display options, that include the distribution of hits by taxonomic grouping, sorting by taxonomic proximity, the best hit to each organism, the protein domains in the query sequence, similar sequences that have known 3-D structures, and more. As additional organism-specific genome projects get underway, NCBI is working to integrate the various organism-specific resources with our set of primary resources. The Entrez Map Viewer is a software component of Entrez Genomes. It allows you to view an organism's complete genome, integrated maps (when available) for each chromosome, and sequence data for a region of interest. The organisms currently represented in the Entrez Map Viewer are: Arabidopsis thaliana, Danio rerio (zebrafish), Drosophila melanogaster, Homo sapiens, Mus musculus, Zea mays (corn), Oryza sativa (rice), Hordeum vulgare (barley), Triticum aestivum (bread wheat). Medicago truncatula and Plasmodium falciparum are under construction. The website will continue to evolve as more sequence enters the public domain, offering general display and analysis tools for all sequences, as well as resources tailored for selected organisms or sequence types. The Entrez Genomes home page is at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Genome .


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