Agricultural Microbes Genome 2 Conference Agricultural Microbes Genome 2 Conference
Session: Sequencing
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Salmonella Pullorum, Salmonella Choleraesuis, and Salmonella Dublin are closely related Salmonella serovars that are adapted to different animal hosts: S. Pullorum is a primary poultry pathogen, S. Choleraesuis is a primary swine pathogen, and S. Dublin is a primary bovine pathogen. These three Salmonella serovars cause severe, often fatal, diseases in farm animals. Although the closely related Salmonella serovars have distinct differences in host adaptation and pathogenesis, it is not known why they are adapted to specific hosts, or why they have unique virulence traits. Each of these serovars has a core of common genes which are essential for growth in vitro and in vivo, and a set of unique genes that define the unique virulence attributes in a particular host. To identify the serovar-specific differences, we are sample sequencing the genomes of several Salmonella serovars, and comparing the genome sequences of multiple closely related Salmonella serovars. The genome sequences of the serovars Salmonella Enteritidis (UIUC), Salmonella Typhimurium (Washington University), Salmonella Paratyphi (Washington University), and Salmonella Typhi (Sanger Center) are available, and the sample sequencing of Salmonella Dublin is nearly complete (see http://salmonella.org). Useful software tools developed for the comparative analysis of Salmonella, and our initial conclusions from the comparisons of the available genome sequences will be described.